L-(+)-Lactic Acid, Calcium Salt
Calcium lactate
CAS: 814-80-2;5743-48-6
Molecular Formula: C3H8CaO3
L-(+)-Lactic Acid, Calcium Salt - Names and Identifiers
| Name | Calcium lactate |
| Synonyms | calphosan Conclyte Ca Calcium lactate L-Calcium Lactate calcium dilactate Calcium DL-lactate CALCIUM LACTATE, TRIHYDRATE L-(+)-Lactic Acid, Calcium Salt LACTIC ACID CALCIUM SALT, TRIHYDRATE 2-HYDROXYPROPANOIC ACID CALCIUM SALT, TRIHYDRATE |
| CAS | 814-80-2 5743-48-6 |
| EINECS | 212-406-7 |
| InChI | InChI=1/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2 |
L-(+)-Lactic Acid, Calcium Salt - Physico-chemical Properties
| Molecular Formula | C3H8CaO3 |
| Molar Mass | 132.17 |
| Boling Point | 120℃ |
| Solubility | Soluble in water, freely soluble in boiling water, very slightly soluble in ethanol (96 per cent). |
| Appearance | White powder |
| PH | 7.56(1 mM solution);7.97(10 mM solution);8.28(100 mM solution);8.5(1000 mM solution) |
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | White granules or powder. Slightly weathered in the open air. Water of crystallization was lost at 120 °c. Soluble in cold water, soluble in hot water, insoluble in ethanol, ether or chloroform |
| Use | Used as food additives, children's nutrition food fortifier, medical for calcium supplement |
L-(+)-Lactic Acid, Calcium Salt - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| TSCA | Yes |
L-(+)-Lactic Acid, Calcium Salt - Upstream Downstream Industry
| Raw Materials | L(+)-Lactic acid Calcium hydroxide Calcium hydroxide DL-Lactic acid DL-Lactic acid Calcium carbonate Calcium carbonate |
L-(+)-Lactic Acid, Calcium Salt - Reference
| Reference Show more | 1. [IF=2.87] Li Zhongmin et al."Preparation and regeneration of a thermo-sensitive adsorbent material: methyl cellulose/calcium alginate beads (MC/CABs)."Polym Bull. 2020 Apr;77(4):1707-1728 |
L-(+)-Lactic Acid, Calcium Salt - Nature
Open Data Verified Data
White to milky white crystals or powder, odorless and tasteless. Soluble in hot water into a transparent or slightly cloudy solution, insoluble in ethanol, chloroform and ether. The pH of the aqueous solution was 6.0 to 7.0. There is easy weathering in the air, heated to 120 deg C loss of water of crystallization.
Last Update：2024-01-02 23:10:35
L-(+)-Lactic Acid, Calcium Salt - Preparation Method
Open Data Verified Data
The food additive calcium lactate was prepared by direct extraction of starch and saccharides by inoculating Lactobacillus and synthesis of lactic acid and calcium hydroxide (or calcium carbonate).
Last Update：2022-01-01 10:09:15
L-(+)-Lactic Acid, Calcium Salt - Standard
Authoritative Data Verified Data
This product is calcium alpha-hydroxypropionate pentahydrate. The content of C6Hl0CaO6 shall be between 98.0% and 103.0% based on the dry product.
Last Update：2024-01-02 23:10:35
L-(+)-Lactic Acid, Calcium Salt - Trait
Authoritative Data Verified Data
- This product is white or white crystalline or granular powder; Almost odorless; Slightly weathered.
- This product is soluble in hot water, soluble in water, almost insoluble in ethanol, chloroform or ether.
Last Update：2022-01-01 13:36:57
L-(+)-Lactic Acid, Calcium Salt - Use
Open Data Verified Data
calcium Nutrition Fortifier. High calcium content, easy absorption, good safety, wide application range. It can also be used as a stabilizer, buffer, dough regulator, improve the quality of food, and prevent the fading of fruits and vegetables.
Last Update：2022-01-01 10:09:15
L-(+)-Lactic Acid, Calcium Salt - Differential diagnosis
Authoritative Data Verified Data
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 254).
- This product shows the identification reaction of calcium salt and lactate (General rule 0301).
Last Update：2022-01-01 13:36:58
L-(+)-Lactic Acid, Calcium Salt - Exam
Authoritative Data Verified Data
acidity
take L. 0g of this product, add 20ml of warm water to dissolve and cool, add 2 drops of phenolphthalein indicator solution and 0.50ml of sodium hydroxide titration solution (0.lmol/L), which should be pink.
clarity and color of solution
Take 7.LG of this product, add water 100ml to dissolve, the solution should be clear and colorless; If it is turbid, it should not be more concentrated compared with No. 2 Turbidity standard solution (General rule 0902-method); If it is colored, comparison with yellow No. 2 Standard Colorimetric solution (General rule 0901 first method), not deeper.
chloride
take 0.10g of this product and check it according to law (General rule 0801). Compared with the control solution made of 0.05% of standard sodium chloride solution, it should not be more concentrated ().
sulfate
take 0.40g of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.075% of standard potassium sulfate solution, it should not be more concentrated ().
loss on drying
take this product, dry to constant weight at 125°C, weight loss should be 26.0% ~ 31.0% (General 0831).
magnesium and alkaline salts
take 7.lg of this product, add 100ml of water to dissolve, shake well, take 20ml, add 20ml of water, 2g of ammonium chloride and 2ml of 6mol/L ammonia solution, after heating to boiling, rapidly heat 40ml of 4% ammonium oxalate solution, shake well, place for 4 hours, dilute to 0.5ml with water, shake well, filter, take 50ml of continued filtrate, add ml of sulfuric acid, after evaporation to dryness in a water bath, the residue should not exceed 5mg by ignition to constant weight at 600°C.
barium salt
take this product l. After adding 20ml of water to dissolve, it is divided into two equal parts, one part is used as a control tube, the other part is added with 1ml of calcium sulfate test solution, and is left for 15 minutes. Compared with the control tube, it should not be more concentrated.
Iron Salt
take 0.50g of this product, add 0807 of water, heat and dissolve in a water bath, let it cool, and check according to law (general rule), no deeper (0.005%) compared to standard iron solution l of control solution made by the same method.
Heavy metals
take this product l. Add 15ml of water and 2m l of acetate buffer (pH 3.5) to dissolve and cool, add appropriate amount of water to make 25ml, and check according to law (General rule 0821, Law 1), heavy metals should not be more than 10 parts per million.
arsenic salt
take l.Og of this product, add 5ml of hydrochloric acid and 23ml of water to dissolve, check according to law (General rule 0822 first law), should comply with the provisions (0.0002%).
Last Update：2022-01-01 13:36:59
L-(+)-Lactic Acid, Calcium Salt - Content determination
Authoritative Data Verified Data
take about 0.3g of this product, precision weighing, add 100ml of water, heat to dissolve, cool, add 15ml of sodium hydroxide test solution and about 0.lg of caldansin indicator, with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) titration solution from purple to pure blue. Each 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) is equivalent to 10.91mg of C6Hl0CaO6.
Last Update：2022-01-01 13:36:59
L-(+)-Lactic Acid, Calcium Salt - Category
Authoritative Data Verified Data
calcium supplement.
Last Update：2022-01-01 13:36:59
L-(+)-Lactic Acid, Calcium Salt - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 13:36:59
L-(+)-Lactic Acid, Calcium Salt - Calcium lactate tablets
Authoritative Data Verified Data
This product contains calcium lactate (C6Hl0CaO6 • 5H20) should be 95.0% to 105.0% of the label.
trait
This product is white tablet.
identification
take an appropriate amount of fine powder of this product (about equivalent to lg of calcium lactate), add 20ml of water, heat to dissolve calcium lactate, filter, and identify the filtrate calcium salt and lactate reaction (General 0301).
examination
The relevant provisions under tablets (General rule 0101) should be met, except that the disintegration time should be within 20 minutes.
Content determination
Take 10 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about 0.3g equivalent to calcium lactate), add 100ml water, heat to dissolve calcium lactate, cool, according to the method under the determination of calcium lactate content, from the "addition of sodium hydroxide test solution 15ml", according to the law. Each 1 ml of ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) corresponds to 15.42mg of c6h10cao 6.5H20.
category
Same as calcium lactate.
specification
(1)0.25g (2)0.3g (3)0.5g
storage
sealed storage.
Last Update：2022-01-01 13:37:00
L-(+)-Lactic Acid, Calcium Salt - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | calcium lactate, white particles or powder, soluble in hot water, insoluble in ethanol, ether or chloroform; it is a good medicine to supplement calcium and an ideal additive for calcium-fortified food. It can reduce the permeability of capillaries, maintain the normal excitability of nerves and muscles, and assist in the prevention and treatment of various allergic diseases, maintain vigorous energy and physical strength and other effects; At the same time, it also has the advantages of high solubility, large physiological tolerance, and acid root is directly absorbed and metabolized without retention; therefore, it is considered to be an extremely ideal calcium substance. It can be used in medicine to treat calcium deficiency and allergic diseases, and can also be used as a coagulant. In food often as a calcium fortifier, children, the elderly, pregnant women and other essential calcium substances. It is also commonly used as a hardening agent in the processing of fruit and vegetable foods. As a feed additive in the feed industry, it can increase the yield of milk, reduce the rate of broken eggs, and promote the growth of young animals. |
| preparation method | 1. Direct neutralization of egg shell (1) eggshell pretreatment: first, the eggshell is placed in a cleaning pool, and the eggshell is soaked in water at 20 ° C for 30 min. The ratio of eggshell to water is 1: (2~2.5). Wash the soaked eggshell with clean water to remove the dirt attached to the eggshell. The washed eggshell was then placed in a 55 ° C. Tunnel blast dryer and dried for 12 hours. The dried eggshell was crushed, sieved through a 40-mesh sieve, and stored for later use. (2) neutralization reaction: weigh 10 g of eggshell powder into a 250 mL beaker, slowly add a certain amount of lactic acid to react with it, and add 100 mL distilled water into the reaction system for 3 times, in order to prevent the occurrence of discharge phenomenon need to add water while stirring. Water Bath constant temperature control reaction temperature, when no more bubbles when the reaction is complete. (3) Suction filtration and concentration: After the reaction is complete, the temperature is raised to 70 ° C, the generated calcium lactate is dissolved, and the mother liquid of calcium lactate is obtained by hot Suction filtration, and then the mother liquid is heated and concentrated, when the concentration of calcium lactate in the mother liquor reached 145~155g/L, the crystals were cooled and left to stand for 24 h. Separation of crystals and mother liquor, due to the greater solubility of calcium lactate in water, there are still a lot of calcium lactate in the crystallization of mother liquor, concentrated again after crystallization, combined crystals. (4) elution and drying: an appropriate amount of anhydrous ethanol was added to wash the calcium lactate crystals produced by the reaction, and the unreacted lactic acid and other residues attached to the surface were removed. The alcohol-washed calcium lactate is placed in an electric heating blast drying oven and is dried at a low temperature and static state. The drying temperature is not higher than 80 ℃ and the drying time is 8-12 h, when the mass fraction of heating loss of calcium lactate is 15% ~ 20%, white powder calcium lactate can be obtained by crushing, sieving and packaging. 2. The preparation process of calcium lactate from cuttlebone is as follows: take cuttlebone powder 2.50g → put it in an Erlenmeyer flask → add 85% lactic acid → shake → place it in a constant temperature water bath to react → dilute and wash with evaporating water at the same temperature → filter with suction → put the filtering liquid in a small beaker → place it heating and evaporating in a constant temperature water bath to about 10ml → cooling a small beaker of the remaining small amount of solution → cooling and precipitating crystals in a refrigerator at 4 ℃ → washing white crystals with 35ml of anhydrous ethanol → filtering → drying in a constant temperature drying oven at 80 ℃-White calcium lactate crystals were obtained. 3. The eggshell powder after a certain amount of separated shell membrane is weighed by double firing method, and is calcined at high temperature in a maogu furnace to obtain white calcium oxide eggshell ash. Add a certain concentration of dilute hydrochloric acid, the eggshell ash dissolution, filtration, removal of acid insoluble matter, filtrate with a certain concentration of sodium carbonate solution, so that the complete generation of calcium carbonate precipitation, centrifugal separation, washing, water-soluble salts were removed. The high-purity calcium carbonate was dried in an oven at 1 10 ℃ and transferred to a high-temperature satin burning in a Maoguo furnace to obtain high-purity ash calcium oxide. A certain amount of water is added to Finely grind the eggshell ash to make a milk of lime, and a human lactic acid solution is slowly added under constant stirring, and the solution is further stirred until the solution is clear, and the solution is left to stand and filtered. After the filtrate was appropriately concentrated, it was naturally crystallized at low temperature. After natural crystallization, dissolve, filter, concentrate the mother liquor properly, place the natural crystals several times, collect the combined crystals, wash with cold distilled water, and concentrate properly, it was then dried in a drying oven at 102 ° C. To obtain anhydrous calcium lactate as a white powder. Calcium Lactate was directly produced from corn or dried potato by fermentation. The process route is shown in Figure 1. Figure 2 is the process flow diagram of the fermentation method |
| Application | 1. In medicine can be used for the treatment of calcium deficiency, such as tetany, skeletal dysplasia, rickets; Also for hypocalcemia in patients with chronic renal failure; Can also be used for allergic diseases and tuberculosis adjuvant therapy; it can also be used as a coagulant. 2. Food additives, used as calcium Food Nutrition Fortifier, used in baby food, dairy products, bread, cakes, candy, soy products, pickled vegetables, etc., this product as a calcium supplement is more easily absorbed than other products; Used as bread, buffer and leavening agents for cakes. It is also often used as a hardening agent in the processing of fruit and vegetable foods. As a feed additive in the feed industry, it can increase the yield of milk, reduce the rate of broken eggs, and promote the growth of young animals. (2015-11-16) |
| usage and dosage | tablet: 0.25g, 05g. Oral. Adults each 1~4g, children 0.3~0.6g, 2~3 times a day, must be taken with vitamin D, in order to promote the absorption of calcium. Calcium tablets: 0.5g. Sweet, suitable for children to take, because of less calcium, must use 1.5~2 times the amount of calcium lactate. |
| adverse reactions | may cause belching, constipation, abdominal discomfort, etc. High dose or overdose can cause hypercalcemia, manifested as loss of appetite, Nausea, Vomit, constipation, Abdominal Pain, arrhythmia and bone lime deposition. |
| identification test | calcium salt test (IT-10) and lactate test (IT-20) of 5% sample solution positive. |
| content analysis | accurately weigh a sample corresponding to about 350mg of calcium lactate (c6h10cao 6) and dissolve in a test solution containing 2ml of dilute hydrochloric acid (TS-117) 150ml of water. Under stirring (preferably with a magnetic stirrer), add 0.05mol/L disodium EDTA to about 30ml with a 50ml burette, add 15ml of sodium hydroxide solution (TS-224) and 300mg of hydroxyphenol blue indicator, titration was continued to the blue end point. Per ml,0.05mol/L EDTA disodium corresponds to 10.91mg of calcium lactate (c6h10cao). |
| toxicity | ADI is not restrictive (FAO/WHO,2001). GRAS(FDA,§ 184.1207,2000). |
| Use limit | GB 14880-94: cereals and their products, beverages, 12-24g/kg; Foods for infants and young children, 23~46g/kg. GB 2760-2002(g/h;L-calcium lactate and DL-calcium lactate limits are the same): chicken egg yolk powder 3~5; Chicken protein powder 1.5~2.5; Chicken whole egg powder 2.25~3.75; jelly 3~6; Soft drinks 1.2~10.4; Chewing gum GMP; Fried potato chips seasoning 10; Fried potato chips 1. FDA,§ 184.1207(2000): No restrictions (GMP). USDA,§ 318.7: product formulation, 0.6%. FAO/WHO(1984): jam and jelly, orange peel jelly, keeping the pH at 2.8-3.5,200mg/kg (Ca); Canned tomato, 800mg/kg (D or flaky),450mg/kg (self-contained) (Ca); Grapefruit, green beans, strawberry, fruit salad and other canned 350mg/kg (Ca); Cucumber 250mg/kg; Cold drinks, edible caseinate, according to GMP. As a calcium fortifier, it can be used in bread, other confectionery products, wheat flour, milk powder, tofu, fermented soybean paste, pickled vegetables and so on. The absorption rate of calcium is the best. Used as bread, cake (0.25% of the amount) of the buffer, leavening agent. In addition, according to Japanese regulations, the maximum dosage is 7.7% (≤ 1% calculated as calcium). |
| Use | calcium lactate is a good food calcium fortifier, absorption effect is better than inorganic calcium. Can be used for infant food, the use of 23~46g/kg; In cereals and their products for 12~24g/kg; In drink and milk drinks for 3~6 g/kg. It is also used as a leavening agent and buffer for bread baking powder. calcium lactate is a good dietary calcium fortifier with better absorption than inorganic calcium. The calcium agent used as a Nutrition Fortifier is used as a buffer and leavening agent for bread, cake, etc. Can also be used for bread, cakes, flour food, market milk powder, tofu, soybean paste, pickled products. As a fortifier it is easily absorbed with other calcium species. As a drug use, can prevent calcium deficiency, such as rickets, tetany, as well as women's pregnancy, lactation need calcium supplement. It is used as a food additive and a fortifier for children's nutritional food, and is used to supplement calcium |
| production method | the rice was gelatinized under high pressure, diluted with water and cooled to 50-53 ℃, and then mixed with Aspergillus niger and Lactobacillus delbrueckii, fermentation to obtain metabolites of lactic acid, and then add calcium phosphate neutralization, to obtain crude calcium lactate, and finally refined, or calcium carbonate and dilute lactic acid solution, and then the solution is evaporated to produce. The refining process is the use of magnesium chloride and calcium hydroxide generated by the role of magnesium hydroxide, it has the nature of the coagulation, so that some of the impurities in the fermentation broth and protein coagulation after removal, and then vacuum concentration, crystallization, refined calcium lactate. (1) fermentation method. Calcium carbonate was used as a neutralizing agent for lactic acid fermentation, and calcium lactate was directly produced by secondary crystallization after neutralizing the fermentation broth with lime water. Fermentation raw materials can be used for rice gelatinization saccharification liquid or rice flour (corn flour) double enzyme hydrolysate, and specific reference is made to lactic acid fermentation. (2) neutralization method. Calcium hydroxide or calcium oxide is added to 50% of the final product lactic acid solution for neutralization reaction, and then insoluble impurities are removed by filtration, and then cooled to crystallize, separate and dry to obtain the final product. This method is simple, but the cost is higher. lactic acid fermentation using calcium carbonate as neutralizer, Calcium Lactate was directly produced by secondary crystallization after the fermentation broth was neutralized with lime water. Fermentation raw materials can be used for rice gelatinization saccharification liquid or rice flour (corn flour) double enzyme hydrolysate, and specific reference is made to lactic acid fermentation. Neutralization method calcium hydroxide or calcium oxide is added to 50% of the finished lactic acid solution for neutralization reaction, and then insoluble impurities are removed by filtration, and then cooled to crystallize, separate and dry to obtain the finished product. This method is simple, but the cost is higher. 2C3H6O3+Ca(OH)2→(C3H5O3)2Ca+2H2O |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | intravenous-mouse LD50: 140 mg/kg |
| flammability hazard characteristics | thermal decomposition of spicy and irritating smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | water, dry powder, carbon dioxide, foam |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:32:08
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Raw Materials for L-(+)-Lactic Acid, Calcium Salt